According to analysts, Cairo will use the summit to underscore its strategic autonomy, showing it can leverage its close ties with both Washington and Beijing.
Sisi, in an op-ed published in Egyptian media on Tuesday, highlighted Cairo’s “independent foreign policy”, days after a branch of Egypt’s second-largest bank was targeted by US sanctions.
Washington vowed last month to isolate Iran economically, threatening expanded sanctions that could also hit Chinese banks, among others.
China, a major buyer of Iranian oil, has vowed to safeguard its interests.
In the lead-up to an expected meeting between Xi and US President Donald Trump this month, it has also sought to shore up ties with US-friendly regional nations.
Egypt is one of the largest recipients of US military aid, and historically a key Middle East mediator.
Last week, the US Treasury announced sanctions on the Emirati branch of Egypt’s Banque Misr for alleged support to Iran.